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We should consider (outside of ethical considerations - but no effective substitute has yet to be found) that such tests generally are based on either acute oral (by mouth) or injected lethal doses.
This means that the LD50 dose represents the median toxic dose taken all at one time, either by ingesting or by direct injection of the test compound.
Practitioner training, even up to the present day, has tended to concentrate more on massage and other application methods, than on an in-depth understanding of essential oils from both the chemical/pharmacological viewpoint and their full history of use in traditional medicine. Maury also stated her own preference to avoid the more "medical" applications of essential oils, including internal use.
Such applications, she felt, were best left to medical practitioners. Maury, the growth of "Holistic" Aromatherapy continued primarily in England by those influenced by her, such as Marceline Arcier and Daniele Ryman.
The vast majority of Aromatherapy books are written for the lay public.
In this regard, care is taken to recommend dosages and essential oils that will neither create negative reactions nor lawsuits.
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The "median dosages" are then generally given in the ratio of grams of test compound per kilogram of bodyweight.
What can be noted in many publications are statements that are based on the attitude that if an author does not know about the realities of the possible negative effects of an essential oil, then, if any possible negative effect might be noted, the invariable recommendation is to avoid the use of that essential oil or to use extremely low dosages.